RNDr. Zuzana Neščáková, PhD.

Research

Scientific background: biomaterials, biology, microbiology, immunology and cell-biology;

At the Dep. of Biomaterials have been developing new biomaterials with applications in regenerative medicine of hard and soft tissue and for delivery of the drugs. One of the main approach is the understanding of interactions between proposed biomaterials and biosystem. My research involves multidisciplinary study of developing materials in the terms of biocompatibility, biodegradability, bioresorbability and bioactivity. Additionally, cell-material interactions such as cytocompatibility, antibacterial activity, osteogenic and angiogenic activity has been investigated.

International projects:

HORIZON 2020, WIDESPREAD-01-2016-2017-TeamingPhase2, Centre for functional and surface-functionalized glasses, 3/2017 – 2/2024, investigator

National projets:

VEGA 1/0431/18 The relationship between composition, structure and properties of inorganic-organic nanocomposite film for protection of materials, investigator

Publications

Publication activity:

Korolenko, TA; Johnston, TP; Machova, E; Bgatova, NP; Lykov, AP; Goncharova, NV; Nescakova, Z; Shintyapina, AB; Maiborodin, IV; Karmatskikh, OL. Hypolipidemic effect of mannans from C. albicans serotypes A and B in acute hyperlipidemia in mice. Int. J. Biol. Macromol. 107 (2018), 2385-2394. DOI: 10.1016/j.ijbiomac.2017.10.111

Korolenko, T ; Johnston, TP ; Lykov, AP ; Shintyapina, AB; Khrapova, MV ; Goncharova, NV ; Korolenko, E; Bgatova, NP ; Machova, E; Nescakova, Z. A comparative study of the hypolipidaemic effects of a new polysaccharide, mannan Candida albicans serotype A, and atorvastatin in mice with poloxamer 407-induced hyperlipidaemia. J. Pharm. Pharmacol. 68 (2016), 1516-1526. DOI: 10.1111/jphp.12633

Cizova, A ; Nescakova, Z; Malovikova, A; Bystricky, S. Preparation and characterization of cationic and amphoteric mannans from Candida albicans. Carbohydr. Polym. 149 (2016), 1-7. DOI: 10.1016/j.carbpol.2016.04.083

Liu, M ; Machova, E; Nescakova, Z; Medovarska, I; Clemons, KV ; Martinez, M; Chen, V; Bystricky, S; Stevens, DA . Vaccination with mannan protects mice against systemic aspergillosis. Med. Mycol. 50 (2012), 818-828. DOI: 10.3109/13693786.2012.683539

Nescakova, Z ; Bystricky, S. B cells – ontogenesis and immune memory development. Gen. Physiol. Biophys. 30 (2011), 1-10. DOI: 10.4149/gpb_2011_01_1

Teaching

Doctoral studies:

Study part: Profile subjects:

Inorganic technologies and materials I

Modules:

Biomaterials: Introduction, Biomaterials: Preparation, characterization and use,

Scientific part:

Supervisor of PhD. students

Experimental work I-IX, Publication activity I and II, Active participation in a conference I and II

2015: PhD: Comenius University in Bratislava, Faculty of Natural Sciences, external educational institution – Slovak Academy of Sciences, Institute of Chemistry, Dep. of Immunochemistry of Glycoconjugates. PhD Thesis: Study of the immune response elicited by glycoconjugates prepared from surface saccharides of Candida albicans.

2011: RNDr.: Comenius University in Bratislava, Faculty of Natural Sciences, Dep. of Microbiology and Virology. RNDr. Thesis: Isolation and characterization of the mannan obtained from yeast and hyphae of Candida albicans.

2008: MSc. : Comenius University in Bratislava, Faculty of Natural Sciences, Dep. of Microbiology and Virology. Diploma Thesis: The expression and role of CR3-RP protein in adherence of clinically significant yeast Candida albicans and Candida glabrata.

2006: Bc.: Comenius University in Bratislava, Faculty of Natural Sciences. Bc Thesis: Study of the virulence and pathogenicity factors of Candida sp.

Awards, scholarships and research stays:

2017-2018 – Erlangen-Nuremberg , The Institute of Biomaterials, FAU (Prof. Aldo R. Boccaccini)

4/2011 – Barcelona, Departmento de Ciencias Fisiologiques, Universitat de Barcelona

9/2011 – Novosibirsk, Institute of Physiology, Russian Academy of Sciences

Other activities: